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©2018 by Wai-Lung Ng, Ph.D.  Designed by 

Wai-Lung Ng

吳濰龍

Assistant Professor

School of Pharmacy

Faculty of Medicine

The Chinese University of Hong Kong

Email: billyng@cuhk.edu.hk

Professor Ng research interests are chemical biology, drug discovery, and medicinal chemistry. He completed his postdoctoral training at Harvard Medical School / Dana-Farber Cancer Institute. Prior to Harvard, he was a research fellow at University of Oxford, with funding supports from the Croucher Foundation and Marie Curie Fellowship (declined). He was a Fulbright Scholar at Massachusetts Institute of Technology (MIT) during his graduate study. He obtained his Ph.D. and B.Sc. (1st Class Hons.) in Chemistry from the Chinese University of Hong Kong (CUHK). 

Research

Training

2016 − 2019

2014 − 2016

Harvard Medical School / Dana-Farber Cancer Institute

Broad Institute

Research Fellow in Medicine

Mentor: Prof. Jun Qi

University of Oxford

Croucher Foundation Postdoctoral Fellow

Mentor: Prof. Benjamin G. Davis, FRS

Education

2013 − 2014

 

2010 − 2014

2007 − 2010

Massachusetts Institute of Technology (MIT)

Fulbright Scholar (Visiting Ph.D. student) 

Mentor: Prof. Stephen L. Buchwald

 

The Chinese University of Hong Kong

Ph.D. in Chemistry; Hong Kong PhD Fellowship Awardee

Mentor: Prof. Tony K. M. Shing

B.Sc. in Chemistry (1st Class Hons.); Minor in Environmental Science

Fellowships

2016

2014 − 2016

2013 − 2014

2010 − 2014

Marie Skłodowska-Curie Fellowship (gratefully declined)

Croucher Foundation Postdoctoral Fellowship

Fulbright-Lee Hysan Research Fellowship

Hong Kong PhD Fellowship

Honors

2016

2016

2015

2013

2012

2010

2009, 2007

2009, 2008, 2007

2009, 2008, 2007

2009

2009

2008

2007

Best Poster Presentation Award, Oxford Synthesis Conference 

Travel Award of International Symposium on Chemical Biology 

Selected Participant of 65th Lindau Nobel Laureate Meeting 

Global Scholarship Programme for Research Excellence Award 

Professor Charles K. Kao Student Creativity Awards - First Runner-up 

T C Cheng Postgraduate Scholarship

College Head List 

Dean’s Honours List 

Dr. James C.N. Ma Memorial Scholarship 

Ma Chao Or Memorial Scholarship

Professor Lau Oi-wah Memorial Scholarship 

Social Service Award Scheme – Bronze Medal 

Wong Man Hop Scholarship 

Publications

1. "Epigenome-wide CRISPR/Cas9 screen identifies vulnerabilities of Kras-driven lung cancer” Manuscript in preparation.

2. W.-L. Ng, T. K. M. Shing, “Synthetic and Biological Studies of Carbasugar SGLT2 Inhibitors”, J. Syn.

Org. Chem. Jpn., 2018, 76, 1215−1222.

*This is an invited review article.

 

3. S. R. G. Galan, J. R. Wickens, J. Dadova, W.-L. Ng, X. Zhang, R. A. Simion, R. Quinlan, E. Pires, R. S.

Paton, S. Caddick, V. Chudasama, B. G. Davis, “Post-Translational Site-selective Protein Backbone α-

Deuteration”, Nat. Chem. Bio., 2018, 14, 955.

 

4. W.-L. Ng, A. W. H. Wong, T. K. M. Shing, “Renewable Resource-Based Building Blocks/ Chirons for

the Total Synthesis of Natural Products”. In Efficiency in Natural Product Total Synthesis. P.-Q. Huang,

Z.-J. Yao, R. P. Hsung., eds. Wiley, New York, 2018, 345. ISBN: 978-1-118-94022-8.

 

5. M. Imiołek, G. Karunanithy, W.-L. Ng, A. J. Baldwin, V. Gouverneur, B. G. Davis, “Selective Radical

Trifluoromethylation of Native Residues in Proteins”, J. Am. Chem. Soc., 2018, 140, 1568.

 

6. W.-L. Ng, H.-C. Li, K.-M. Lau, A. K. N. Chan, C. B.-S Lau, T. K. M. Shing, “Concise and

Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition”, Sci. Rep., 2017, 7, 5581.

 

7. H. M. Lai, W.-L. Ng, S. M. Gentleman, W. Wu, “Chemical Probes for Visualizing Intact Animal and

Human Brain Tissue”, Cell. Chem. Bio., 2017, 24, 659.

 

8. W.-L. Ng, K.-M. Lau, C. B.-S Lau, T. K. M. Shing, “Palladium-Catalyzed Arylation of Amino-

Carbasugar Enables the Discovery of a Potent and Selective Carbocyclic SGLT2 Inhibitor”,

Angew. Chem. Int. Ed., 2016, 55, 13818−13821.

*This article was highlighted in Synfacts, 2017, 13, 17.

 

9. T. H. Wright, B. J. Bower, J. M. Chalker, G. J. Bernardes, R. Wiewiora, W.-L. Ng, R. Raj, S. Faulkner,

M. R. J. Vallée, A. Phanumartwiwath, O. D. Coleman, M.-L. Thézénas, M. Khan, S. R. G. Galan, L.

Lercher, S. Gerstberger, M. E. Palm-Espling, B. M. Kessler, T. D.W. Claridge, S. Mohammed, B. G.

Davis, “Post-translational mutagenesis: a chemical strategy for exploration of protein side-chain

diversity”, Science, 2016, 354, 597.

*This article was highlighted in C&EN News, 2016, vol. 94, issue 38, and was also featured in Science,

2016, 354, 553 & Nature Method, 2016, 13, 907.

 

10. H. M. Lai, A. K. L. Liu, W.-L. Ng, J. DeFelice, W. S. Lee, H. Li, W. Li, H. M. Ng, R. C.-C. Chang, B.

Lin, W. Wu, S. M. Gentleman, “Rationalisation and Validation of an Acrylamide-Free Procedure in

Three-Dimensional Histological Imaging”, PLoS One, 2016, 11, e0158628.

 

11. T. K. M. Shing, W.-L. Ng, J. Y.-W. Chan, C. B.-S Lau, “Design, Syntheses and SAR Studies of

Carbocyclic Analogues of Sergliflozin as Potent Sodium-dependent Glucose Co-transporter 2 Inhibitors”,

Angew. Chem. Int. Ed., 2013, 52, 8401−8405.

*This article was highlighted in Synfacts, 2013, 9, 1147.

 

12. T. K. M. Shing, Y. Chen, W.-L. Ng, “Carbocyclization of D-Glucose: Syntheses of Gabosine I and

Streptol”, Tetrahedron, 2011, 67, 6001−6005.

 

13. T. K. M. Shing, Y. Chen, W. L. Ng, “Short and Efficient Syntheses of Gabosine I, Streptol, 7-O-Acetylstreptol, 1-epi-Streptol, Gabosine K, and Carba-α-D-glucose from δ-D-Gluconolactone”, Synlett, 2011, 1318−1319.

Patents

1. T. K. M. Shing, W.-L. Ng, H.-C. Li, K.-M. Lau, A. K. N. Chan, C. B.-S. Lau.

Novel compounds for treating diabetes. (Pending)

US Patent Application No. US15/345,252. Filing Date: Nov 7, 2016.

CN Patent Application No. CN 108059589. Filing Date: Dec 12, 2016.

 

2. W.-L. Ng, J. Huang, Y. C. L. Yan, C. S. D. Poon, H. Y. Li.

Chemical probes for in-vivo non-invasive imaging. (Pending)

US Patent Application No. US62/729,998. Filing Date: Sept 11, 2018.

ProfessionalAssociations

Associate member of American Association for Cancer Research (AACR)

Member of International Chemical Biology Society (ICBS) 

Member of American Chemical Society (ACS)

Associate member of Royal Society of Chemistry (RSC)

Other

Publications

《懷念有機化學全合成一代宗師─ 伍德沃德教授》- 科學月刊6月2016第558期

《林島諾貝爾獎論壇》- 科學月刊8月2016第560期

《現代化療的起源》- 科學月刊12月2016第564期

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Captura_de_Tela_2018-10-28_às_10.12.54.p
Captura_de_Tela_2018-10-28_às_10.12.54.p

Media

Coverage

2016

New carbasugars as potential drug molecules - CUHK Press Release link

Making Molecules - Interview by the Croucher Foundation link