November 19, 2019


Despite substantial progress in lung cancer immunotherapy, the overall response rate in KRAS-mutant lung adenocarcinoma (ADC) patients remains low. Combining standard immunotherapy with adjuvant approaches that enhance adaptive immune responses-such as epigene...

November 8, 2018

Abstract: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes. Unfortunately, current therapeutic agents are not so effective that only less than 36% of the patients have been treated satisfactorily. Thus, we set out to investigate novel small-molecule...

September 17, 2018

Abstract: Isotopic replacement has long-proven applications in small molecules. However, applications in proteins are largely limited to biosynthetic strategies or exchangeable (for example, N–H/D) labile sites only. The development of postbiosynthetic, C–1H → C–2H/D r...

August 2, 2018

Book Chapter: “Renewable Resource-Based Building Blocks/ Chirons for the Total Synthesis of Natural Products”. In Efficiency in Natural Product Total Synthesis. P.-Q. Huang, Z.-J. Yao, R. P. Hsung., eds. Wiley, New York, 2018, 345.

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January 5, 2018

Abstract: The incorporation of fluorine can not only significantly facilitate the study of proteins but also potentially modulate their function. Though some biosynthetic methods allow global residue-replacement, post-translational fluorine incorporation would constitu...

July 17, 2017

Abstract: Carbasugar sodium-glucose cotransporter 2 (SGLT2) inhibitors are highly promising drug candidates
for the treatment of Type 2 diabetes mellitus (T2DM). However, the clinical usage of carbasugar SGLT2 inhibitors has been underexplored, due to the lengthy synth...

June 22, 2017

Abstract: Newly developed tissue clearing techniques can be used to render intact tissues transparent. When combined with fluorescent labeling technologies and optical sectioning microscopy, this allows visualization of fine structure in three dimensions. Gene-transfec...

September 28, 2016

Abstract: Selective inhibition of the transporter protein sodium‐glucose cotransporter 2 (SGLT2) has emerged as a promising way to control blood glucose level in diabetes patients. Reported herein is a short and convergent synthetic route towards some small‐molecule SG...

September 22, 2016

Abstract: Post-translational modification of proteins expands their structural and functional capabilities beyond those directly specified by the genetic code. However, the vast diversity of chemically-plausible (including unnatural but functionally relevant) side-chai...

June 30, 2016

Abstract: Three-dimensional visualization of intact tissues is now being achieved by turning tissues transparent. CLARITY is a unique tissue clearing technique, which features the use of detergents to remove lipids from fixed tissues to achieve optical transparency. To...

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