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©2018 by Wai-Lung Ng, Ph.D.  Designed by 

Publications

Fei Li, Qingyuan Huang, Troy A Luster, Hai Hu, Hua Zhang, Wai-Lung Ng, Alireza Khodadadi-Jamayran, Wei Wang, Ting Chen, Jiehui Deng, Michela Ranieri, Zhaoyuan Fang, Val Pyon, Catriona M. Dowling, Ece Bagdatlioglu, Christina Almonte, Kristen Labbe, Heather Silver, Alexandra R Rabin, Kandarp Jani, Aristotelis Tsirigos, Thales Papagiannakopoulos, Peter S. Hammerman, Vamsidhar Velcheti, Gordon J. Freeman, Jun Qi, George Miller & Kwok-Kin Wong

11. In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma

Wai-Lung Ng & Tony K. M. Shing

J. Syn. Org. Chem. Jpn., 2018, 76, 1215-1222.

Full article: 
https://www.jstage.jst.go.jp/article/yukigoseikyokaishi/76/11/76_1215/_pdf/-char/en

10. Synthetic and Biological Studies of Carbasugar SGLT2 Inhibitors (Invited Review) 

Sébastien R. G. Galan, James R. Wickens, Jitka Dadova, Wai-Lung Ng, Xinglong Zhang, Robert A. Simion, Robert Quinlan, Elisabete Pires, Robert S. Paton, Stephen Caddick, Vijay Chudasama, Benjamin G. Davis 

Nat. Chem. Bio., 2018, 14, 955.

Full article: 
https://www.nature.com/articles/s41589-018-0128-y

09. Post-translational site-selective protein backbone α-deuteration

Book Chapter in Efficiency in Natural Product Total Synthesis. P.-Q. Huang, Z.-J. Yao, R. P. Hsung., eds. Wiley, New York, 2018, 345.

08. Renewable Resource-Based Building Blocks/ Chirons for the Total Synthesis of Natural Products

Mateusz Imiołek, Gogulan Karunanithy, Wai-Lung Ng, Andrew J. Baldwin, Véronique Gouverneur, Benjamin G. Davis

J. Am. Chem. Soc., 2018, 140, 1568.

Full article: 
https://doi.org/10.1021/jacs.7b10230

07. Selective Radical Trifluoromethylation of Native Residues in Proteins

Wai-Lung Ng, Ho-Chuen Li, Kit-Man Lau, Anthony K. N. Chan, Clara Bik-San Lau & Tony K. M. Shing 

Sci. Rep., 2017, 7, 5581.

Full article: 
https://www.nature.com/articles/s41598-017-05895-9

06. Concise and Stereodivergent Synthesis of Carbasugars Reveals Unexpected Structure-Activity Relationship (SAR) of SGLT2 Inhibition

Hei Ming Lai, Wai-Lung Ng, Steve M. Gentleman, Wutian Wu

Cell. Chem. Bio., 2017, 24, 659.

Full article: 
https://doi.org/10.1016/j.chembiol.2017.05.015

05. Chemical Probes for Visualizing Intact Animal and Human Brain Tissue

Tom H. Wright, Ben J. Bower, Justin M. Chalker, Gonçalo J. L. Bernardes, Rafal Wiewiora, Wai-Lung Ng, Ritu Raj, Sarah Faulkner, M. Robert J. Vallée, Anuchit Phanumartwiwath, Oliver D. Coleman, Marie-Laëtitia Thézénas, Maola Khan, Sébastien R. G. Galan, Lukas Lercher, Matthew W. Schombs, Stefanie Gerstberger, Maria E. Palm-Espling, Andrew J. Baldwin, Benedikt M. Kessler, Timothy D. W. Claridge, Shabaz Mohammed, Benjamin G. Davis

Science, 2016, 354, 597.

Full article: 
https://doi.org/10.1126/science.aag1465

04. Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity

Wai‐Lung Ng, Kit‐Man Lau, Clara B.‐S. Lau, Tony K. M. Shing

Angew. Chem. Int. Ed., 2016, 55, 13818−13821.

Full article: 
https://doi.org/10.1002/ange.201608758

03. Palladium-Catalyzed Arylation of Amino-Carbasugar Enables the Discovery of a Potent and Selective Carbocyclic SGLT2 Inhibitor

Hei Ming Lai, Alan King Lun Liu, Wai-Lung Ng, John DeFelice, Wing Sang Lee, Heng Li, Wen Li, Ho Man Ng, Raymond Chuen-Chung Chang, Bin Lin, Wutian Wu, Steve M. Gentleman

PLoS One, 2016, 11, e0158628.

Full article: 
https://doi.org/10.1371/journal.pone.0158628

02. Rationalisation and Validation of an Acrylamide-Free Procedure in Three-Dimensional Histological Imaging

Tony K. M. Shing, Wai‐Lung Ng, Judy Y.‐W. Chan, Clara B.‐S. Lau

Angew. Chem. Int. Ed., 2013, 52, 8401−8405.

Full article: 
https://doi.org/10.1002/anie.201302543

01. Design, Syntheses and SAR Studies of Carbocyclic Analogues of Sergliflozin as Potent Sodium-dependent Glucose Co-transporter 2 Inhibitors

201809