A small‐molecule carbohydrate mimic, pseudo‐sergliflozin, was synthesized effectively by a regio‐ and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein—sodium‐dependent glucose cotransporter 2 (SGLT2)—which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent.
Angew. Chem. Int. Ed., 2013, 52, 8401−8405.
Full article at: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201302543